FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
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Smith, Richard , Duguay, Amy , Bakker, Alice , Li, Peng , Weiszmann, Jennifer , Thomas, Melissa R. , Alba, Benjamin M. , Wu, Xinle , Gupte, Jamila , Yang, Li , Stevens, Jennitte , Hamburger, Agnes , Smith, Stephen , Chen, Jiyun , Komorowski, Renee , Moore, Kevin W. , Véniant, Murielle M. and Li, Yang
Publisher
United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and specificity to one of the receptor and coreceptor pairs used by FGF21, FGFR1c and β-Klotho. These Avimers...
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Full title
FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
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TN_cdi_plos_journals_1335054106
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1335054106
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0061432
