Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanis...
Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases. PARG deficiency leads to cell death whilst PARG depletion causes sensitisation to certain DNA damaging agents, implicating PARG as a potential ther...
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Full title
Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives
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TN_cdi_plos_journals_1339597438
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1339597438
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0050889
