Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcr...
Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
CREB mediates the transcriptional effects of glucose and incretin hormones in insulin-target cells and insulin-producing β-cells. Although the inhibition of CREB activity is known to decrease the β-cell mass, it is still unknown what factors inversely alter the CREB signaling pathway in β-cells. Here, we show that β-cell dysfunctions occurring in c...
Alternative Titles
Full title
Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1344197664
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1344197664
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0034860
