Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Alcadein proteins (Alcs; Alcα, Alcβand Alcγ) are predominantly expressed in neurons, as is Alzheimer's β-amyloid (Aβ) precursor protein (APP). Both Alcs and APP are cleaved by primary α- or β-secretase to generate membrane-associated C-terminal fragments (CTFs). Alc CTFs are further cleaved by γ-secretase to secrete p3-Alc peptide along with the re...
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Full title
Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
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TN_cdi_plos_journals_1346597106
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1346597106
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0062431
