Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Der...
Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer's disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precise Aβ species to target is not yet known. Previously, we and others have shown that natural human IgGs...
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Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide
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TN_cdi_plos_journals_1350901783
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1350901783
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0050317
