When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-F...
When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Conventional wisdom holds that the best way to treat infection with antibiotics is to 'hit early and hit hard'. A favoured strategy is to deploy two antibiotics that produce a stronger effect in combination than if either drug were used alone. But are such synergistic combinations necessarily optimal? We combine mathematical modelling, evolution ex...
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Full title
When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition
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TN_cdi_plos_journals_1351863517
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351863517
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1001540
