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A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

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A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351896778

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

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United States: Public Library of Science

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Contents

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50 ≤ 0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular mechanism that results in LJ001's specific inhibit...

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Full title

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

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Record Identifier

TN_cdi_plos_journals_1351896778

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1351896778

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ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1003297

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