Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 depe...
Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression. We show that in vitro FK506, inhibited synthesis of type I collagen polypeptides, without affecting expression of collagen mRNAs. In vivo, administration of FK506 at a dose of 4 mg/kg completely pr...
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Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis
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TN_cdi_plos_journals_1362916832
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1362916832
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0065897
