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Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in hu...

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in hu...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1366366783

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts

About this item

Full title

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts

Publisher

United States: Public Library of Science

Journal title

PloS one, 2013-06, Vol.8 (6), p.e64961

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Colorectal cancer (CRC) is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU) is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα), an enzyme that plays a role in cell proliferation and transformation, has been reported overexpressed in m...

Alternative Titles

Full title

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1366366783

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1366366783

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0064961

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