A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Th...
A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increases β-catenin nuclear translocation and β-cell proliferation but results in lower insulin content. Our c...
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Full title
A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype
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TN_cdi_plos_journals_1367061078
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1367061078
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0066131
