Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV...
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
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Author / Creator
Julien, Jean-Philippe , Sok, Devin , Khayat, Reza , Lee, Jeong Hyun , Doores, Katie J. , Walker, Laura M. , Ramos, Alejandra , Diwanji, Devan C. , Pejchal, Robert , Cupo, Albert , Katpally, Umesh , Depetris, Rafael S. , Stanfield, Robyn L. , McBride, Ryan , Marozsan, Andre J. , Paulson, James C. , Sanders, Rogier W. , Moore, John P. , Burton, Dennis R. , Poignard, Pascal , Ward, Andrew B. and Wilson, Ian A.
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates with a median IC50 less than 0.05 µg ml(-1). Here, we show that three family memb...
Alternative Titles
Full title
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
Authors, Artists and Contributors
Author / Creator
Sok, Devin
Khayat, Reza
Lee, Jeong Hyun
Doores, Katie J.
Walker, Laura M.
Ramos, Alejandra
Diwanji, Devan C.
Pejchal, Robert
Cupo, Albert
Katpally, Umesh
Depetris, Rafael S.
Stanfield, Robyn L.
McBride, Ryan
Marozsan, Andre J.
Paulson, James C.
Sanders, Rogier W.
Moore, John P.
Burton, Dennis R.
Poignard, Pascal
Ward, Andrew B.
Wilson, Ian A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1368616434
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1368616434
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1003342
