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Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

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Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1369310527

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

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United States: Public Library of Science

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Contents

Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking. Here, we bridge this gap by developing an immunohistochemical (IHC) stain that detects a neoepitope created by the proteolyt...

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Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

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TN_cdi_plos_journals_1369310527

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1369310527

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ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0067306

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