The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-tri...
The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase
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United States: Public Library of Science
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English
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United States: Public Library of Science
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T-705 (Favipiravir) is a broad-spectrum antiviral molecule currently in late stage clinical development for the treatment of influenza virus infection. Although it is believed that T-705 potency is mediated by its ribofuranosyl triphosphate (T-705 RTP) metabolite that could be mutagenic, the exact molecular interaction with the polymerase of influe...
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Full title
The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase
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TN_cdi_plos_journals_1399295076
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1399295076
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0068347
