PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme and transcription factor that is involved in inflammatory response, but its role in T cell response remains largely unknown. We show here that PARP-1 regulates the suppressive function of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Specifically, Tregs in mice with a null mutation of...
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Full title
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3
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TN_cdi_plos_journals_1426279644
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1426279644
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0071590
