Is upregulation of BCL2 a determinant of tumor development driven by inactivation of CDH1/E-cadherin...
Is upregulation of BCL2 a determinant of tumor development driven by inactivation of CDH1/E-cadherin?
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Inactivation of CDH1, encoding E-cadherin, promotes cancer initiation and progression. According to a newly proposed molecular mechanism, loss of E-cadherin triggers an upregulation of the anti-apoptotic oncoprotein BCL2. Conversely, reconstitution of E-cadherin counteracts overexpression of BCL2. This reciprocal regulation is thought to be critica...
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Full title
Is upregulation of BCL2 a determinant of tumor development driven by inactivation of CDH1/E-cadherin?
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TN_cdi_plos_journals_1428933974
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1428933974
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0073062
