Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific P...
Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model
About this item
Full title
Author / Creator
Dickey, Jennifer S. , Gonzalez, Yanira , Aryal, Baikuntha , Mog, Steven , Nakamura, Asako J. , Redon, Christophe E. , Baxa, Ulrich , Rosen, Elliot , Cheng, Gang , Zielonka, Jacek , Parekh, Palak , Mason, Karen P. , Joseph, Joy , Kalyanaraman, Balaraman , Bonner, William , Herman, Eugene , Shacter, Emily and Rao, V. Ashutosh
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotoxicity. Iron chelators and other antioxidants have not completely succeeded in mitigating this effect. One hindrance to the development of cardioprotectants is the lack of physiologically-relevant animal models to simultaneously study antitumor activi...
Alternative Titles
Full title
Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1430170933
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430170933
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0070575
