Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and inter...
Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can interact directly with JAK via a unique, conserved re...
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Full title
Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1
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TN_cdi_plos_journals_1430785194
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430785194
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0070536
