Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to ce...
Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Human APOBEC3 enzymes deaminate single stranded DNA. At least five can deaminate mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. However, only one, APOBEC3A, can hypermutate genomic DNA. We analysed the distribution and function of the two APOBEC3A isoforms p1 and p2 in transfected cell lines. Both can transl...
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Full title
Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death
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TN_cdi_plos_journals_1430787196
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430787196
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0073641
