The role of interruptions in polyQ in the pathology of SCA1
The role of interruptions in polyQ in the pathology of SCA1
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
At least nine dominant neurodegenerative diseases are caused by expansion of CAG repeats in coding regions of specific genes that result in abnormal elongation of polyglutamine (polyQ) tracts in the corresponding gene products. When above a threshold that is specific for each disease the expanded polyQ repeats promote protein aggregation, misfoldin...
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Full title
The role of interruptions in polyQ in the pathology of SCA1
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TN_cdi_plos_journals_1430787414
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1430787414
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003648
