Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosph...
Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Systemic Lupus erythematosus (SLE) is an autoimmune disease caused, in part, by abnormalities in cells of the immune system including B and T cells. Genetically reducing globally the expression of the ETS transcription factor FLI1 by 50% in two lupus mouse models significantly improves disease measures and survival through an unknown mechanism. In...
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Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism
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TN_cdi_plos_journals_1431404248
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1431404248
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0075175
