The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Pola...
The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans
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Wang, Xiao Na , Li, Ze Song , Ren, Yu , Jiang, Tao , Wang, Ya Qing , Chen, Min , Zhang, Jun , Hao, Jian Xiu , Wang, Yan Bo , Sha, Ri Na , Huang, Yi , Liu, Xiao , Hu, Jing Chu , Sun, Guang Qing , Li, Hong Gang , Xiong, Cheng Liang , Xie, Jun , Jiang, Zhi Mao , Cai, Zhi Ming , Wang, Jun , Wang, Jian , Huff, Vicki , Gui, Yao Ting and Gao, Fei
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Azoospermia is one of the major reproductive disorders which cause male infertility in humans; however, the etiology of this disease is largely unknown. In the present study, six missense mutations of WT1 gene were detected in 529 human patients with non-obstructive azoospermia (NOA), indicating a strong association between WT1 mutation and NOA. Th...
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Full title
The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans
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TN_cdi_plos_journals_1433014651
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1433014651
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003645
