Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Associa...
Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association
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Author / Creator
Huang, Hong-Ling , Wang, Shimin , Yin, Meng-Xin , Dong, Liang , Wang, Chao , Wu, Wei , Lu, Yi , Feng, Miao , Dai, Chuanyang , Guo, Xiaocan , Li, Li , Zhao, Bin , Zhou, Zhaocai , Ji, Hongbin , Jiang, Jin , Zhao, Yun , Liu, Xin-Yuan and Zhang, Lei
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The evolutionarily conserved Hippo (Hpo) signaling pathway plays a pivotal role in organ size control by balancing cell proliferation and cell death. Here, we reported the identification of Par-1 as a regulator of the Hpo signaling pathway using a gain-of-function EP screen in Drosophila melanogaster. Overexpression of Par-1 elevated Yorkie activit...
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Full title
Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association
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TN_cdi_plos_journals_1433015456
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1433015456
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1001620
