Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology mode...
Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Degradation of certain proteins through the ubiquitin-proteasome pathway is a common strategy taken by the key modulators responsible for stress responses. Kelch-like ECH-associated protein-1(Keap1), a substrate adaptor component of the Cullin3 (Cul3)-based ubiquitin E3 ligase complex, mediates the ubiquitination of two key modulators, NF-E2-relate...
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Full title
Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation
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TN_cdi_plos_journals_1433049770
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1433049770
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0075076
