Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergi...
Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60-80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzyme that synthesizes gamma-amino butyric acid (GABA), the predominant inhibitory neurotransmitter of t...
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Full title
Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss
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TN_cdi_plos_journals_1433799665
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1433799665
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0072921
