Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril F...
Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Aggregation of α-synuclein (αSyn), the primary protein component in Lewy body inclusions of patients with Parkinson's disease, arises when the normally soluble intrinsically disordered protein converts to amyloid fibrils. In this work, we provide a mechanistic view of the role of N-terminal acetylation on fibrillation by first establishing a quanti...
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Full title
Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence
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TN_cdi_plos_journals_1434868899
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1434868899
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0075018
