Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precur...
Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease
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United States: Public Library of Science
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English
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United States: Public Library of Science
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We reported that iron influx drives the translational expression of the neuronal amyloid precursor protein (APP), which has a role in iron efflux. This is via a classic release of repressor interaction of APP mRNA with iron-regulatory protein-1 (IRP1) whereas IRP2 controls the mRNAs encoding the L- and H-subunits of the iron storage protein, ferrit...
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Full title
Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease
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TN_cdi_plos_journals_1440999746
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1440999746
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0065978
