Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin or...
Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development
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Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States) , Danopoulos, Soula , Parsa, Sara , Al Alam, Denise , Tabatabai, Reza , Baptista, Sheryl , Tiozzo, Caterina , Carraro, Gianni , Wheeler, Matthew , Barreto, Guillermo , Braun, Thomas , Li, Xiaokun , Hajihosseini, Mohammad K and Bellusci, Saverio
Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The vertebrate limbs develop through coordinated series of inductive, growth and patterning events. Fibroblast Growth Factor receptor 2b (FGFR2b) signaling controls the induction of the Apical Ectodermal Ridge (AER) but its putative roles in limb outgrowth and patterning, as well as in AER morphology and cell behavior have remained unclear. We have...
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Full title
Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development
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TN_cdi_plos_journals_1445862052
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1445862052
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0076248
