Differences in the binding affinities of ErbB family: heterogeneity in the prediction of resistance...
Differences in the binding affinities of ErbB family: heterogeneity in the prediction of resistance mutants
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The pressure exerted by drugs targeted to a protein in any therapy inevitably leads to the emergence of drug resistance. One major mechanism of resistance involves the mutation of key residues in the target protein. Drugs that competitively replace a natural substrate are often made ineffective by mutations that reduce the drug's affinity relative...
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Full title
Differences in the binding affinities of ErbB family: heterogeneity in the prediction of resistance mutants
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TN_cdi_plos_journals_1445887231
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1445887231
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0077054
