The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleuki...
The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Bacillus Calmette-Guérin (BCG), the only approved tuberculosis vaccine, provides only limited protection. Previously, we generated a recombinant derivative (BCG ΔureC::hly), which secretes the pore-forming toxin listeriolysin O (LLO) of Listeria monocytogenes. This vaccine shows superior protection against tuberculosis in preclinical models and is...
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Full title
The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice
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TN_cdi_plos_journals_1458259364
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1458259364
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0078966
