A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington...
A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In Mice
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Full title
Author / Creator
Hölter, Sabine M. , Stromberg, Mary , Kovalenko, Marina , Garrett, Lillian , Glasl, Lisa , Lopez, Edith , Guide, Jolene , Götz, Alexander , Hans, Wolfgang , Becker, Lore , Rathkolb, Birgit , Rozman, Jan , Schrewed, Anja , Klingenspor, Martin , Klopstock, Thomas , Schulz, Holger , Wolf, Eckhard , Wursta, Wolfgang , Gillis, Tammy , Wakimoto, Hiroko , Seidman, Jonathan , MacDonald, Marcy E. , Cotman, Susan , Gailus-Durner, Valérie , Fuchs, Helmut , de Angelis, Martin Hrabě , Lee, Jong-Min and Wheeler, Vanessa C.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. The disease has an insidious course, typically progressing over 10-15 years until death. Currently there is no effective disease-modifying therapy. To better understand the HD patho...
Alternative Titles
Full title
A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In Mice
Authors, Artists and Contributors
Author / Creator
Stromberg, Mary
Kovalenko, Marina
Garrett, Lillian
Glasl, Lisa
Lopez, Edith
Guide, Jolene
Götz, Alexander
Hans, Wolfgang
Becker, Lore
Rathkolb, Birgit
Rozman, Jan
Schrewed, Anja
Klingenspor, Martin
Klopstock, Thomas
Schulz, Holger
Wolf, Eckhard
Wursta, Wolfgang
Gillis, Tammy
Wakimoto, Hiroko
Seidman, Jonathan
MacDonald, Marcy E.
Cotman, Susan
Gailus-Durner, Valérie
Fuchs, Helmut
de Angelis, Martin Hrabě
Lee, Jong-Min
Wheeler, Vanessa C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1460879798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1460879798
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0080923
