UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin
UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The anticonvulsant ethosuximide has been previously shown to increase life span and promote healthspan in the nematode Caenorhabditis elegans at millimolar concentrations. Here we report that following exposure to ultraviolet irradiation at 254 nm, ethosuximide is converted into a compound that displays toxicity toward C. elegans. This effect is sp...
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Full title
UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin
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TN_cdi_plos_journals_1466544637
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1466544637
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0082543
