OBATOCLAX and ABT-737 Induce ER Stress Responses in Human Melanoma Cells that Limit Induction of Apo...
OBATOCLAX and ABT-737 Induce ER Stress Responses in Human Melanoma Cells that Limit Induction of Apoptosis
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Anti-apoptotic Bcl-2 family proteins, in particular, Mcl-1, are known to play a critical role in resistance of human melanoma cells to induction of apoptosis by endoplasmic reticulum stress and other agents. The present study examined whether the BH3 mimetics, Obatoclax and ABT-737, which inhibit multiple anti-apoptotic Bcl-2 family proteins, would...
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OBATOCLAX and ABT-737 Induce ER Stress Responses in Human Melanoma Cells that Limit Induction of Apoptosis
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TN_cdi_plos_journals_1469701695
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1469701695
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0084073
