Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance...
Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Inhibitors of the mammalian target of rapamycin (mTORi) have clinical activity; however, the benefits of mTOR inhibition by rapamycin and rapamycin-derivatives (rapalogs) may be limited by a feedback mechanism that results in AKT activation. Increased AKT activity resulting from mTOR inhibition can be a result of increased signaling via the mTOR co...
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Full title
Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer
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TN_cdi_plos_journals_1473340904
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1473340904
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0085995
