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Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synucl...

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synucl...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1474857490

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

About this item

Full title

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

Publisher

United States: Public Library of Science

Journal title

PloS one, 2013-11, Vol.8 (11), p.e81426-e81426

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The discovery of the involvement of alpha-synuclein (α-syn) in Parkinson's disease (PD) pathogenesis has resulted in the development and use of viral vector-mediated α-syn overexpression rodent models. The goal of these series of experiments was to characterize the neurodegeneration and functional deficits resulting from injection of recombinant ad...

Alternative Titles

Full title

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1474857490

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1474857490

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0081426

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