Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Inf...
Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH-D-J). We characterized the frequency of SHM in expressed IgG mRNA immunoglobulin transcripts fro...
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Full title
Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection
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TN_cdi_plos_journals_1475120751
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1475120751
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0081913
