Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-...
Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, "high-risk" HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated pro...
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Full title
Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function
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TN_cdi_plos_journals_1477847980
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1477847980
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0084506
