Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathw...
Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in renal secondary hyperparathyroidism. To dissect the role of parathyroid gland resident Klotho in health and disease, we generated mice with a parathyroid-specific Klot...
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Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion
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TN_cdi_plos_journals_1477954360
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1477954360
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003975
