Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman...
Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal deficiency of the imprinted gene UBE3A. Individuals with AS suffer from intellectual disability, speech impairment, and motor dysfunction. Currently there is no cure for the disease. Here, we evaluated the phenotypic effect of activating the silenced paternal allele o...
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Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model
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TN_cdi_plos_journals_1477954437
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1477954437
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004039
