Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation
Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Lactate dehydrogenase A (LDHA) is an important enzyme in fermentative glycolysis, generating most energy for cancer cells that rely on anaerobic respiration even under normal oxygen concentrations. This renders LDHA a promising molecular target for the treatment of various cancers. Several efforts have been made recently to develop LDHA inhibitors...
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Full title
Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation
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TN_cdi_plos_journals_1478266559
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1478266559
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0086365
