LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways
LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways
About this item
Full title
Author / Creator
Smith, Stephen , Tripathi, Rati , Goodings, Charnise , Cleveland, Susan , Mathias, Elizabeth , Hardaway, J. Andrew , Elliott, Natalina , Yi, Yajun , Chen, Xi , Downing, James , Mullighan, Charles , Swing, Deborah A. , Tessarollo, Lino , Li, Liqi , Love, Paul , Jenkins, Nancy A. , Copeland, Neal G. , Thompson, Mary Ann , Du, Yang and Davé, Utpal P.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct patterns of gene expression: one in which there wa...
Alternative Titles
Full title
LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways
Authors, Artists and Contributors
Author / Creator
Tripathi, Rati
Goodings, Charnise
Cleveland, Susan
Mathias, Elizabeth
Hardaway, J. Andrew
Elliott, Natalina
Yi, Yajun
Chen, Xi
Downing, James
Mullighan, Charles
Swing, Deborah A.
Tessarollo, Lino
Li, Liqi
Love, Paul
Jenkins, Nancy A.
Copeland, Neal G.
Thompson, Mary Ann
Du, Yang
Davé, Utpal P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1490992458
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1490992458
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0085883
