Decreased Store Operated Ca2+ Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resista...
Decreased Store Operated Ca2+ Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resistant GSK3
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases cytosolic Ca(2+)-concentration ([Ca(2+)]i), an effect augmented in DCs isolated from mutant mic...
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Full title
Decreased Store Operated Ca2+ Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resistant GSK3
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TN_cdi_plos_journals_1497182610
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1497182610
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0088637
