p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells hapl...
p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome caused by ribosomal protein haploinsufficiency. DBA exhibits marked phenotypic variability, commonly presenting with erythroid hypoplasia, less consistently with non-erythroid features. The p53 pathway, activated by abortive ribosome assembly, is hypothesized to contribu...
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Full title
p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5
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TN_cdi_plos_journals_1499826564
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1499826564
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0089098
