A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through...
A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress, measured by increased NF-κB activity, induces LOI in...
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Full title
A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation
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TN_cdi_plos_journals_1499826584
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1499826584
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0088052
