FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcom...
FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors
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United States: Public Library of Science
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English
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United States: Public Library of Science
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FBXW7 is a tumor suppressor gene responsible for the degradation of several proto-oncogenes. Preclinical data suggest that FBXW7 mutations sensitize cells to mTOR inhibitors. Clinicopathologic characteristics of cancer patients with FBXW7 mutations and their responses to mTOR inhibitors remain unknown.
Using multiplex gene panels we evaluated ho...
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FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors
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TN_cdi_plos_journals_1500411007
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1500411007
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0089388
