Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer
Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Ovarian cancer is the most lethal gynecological disease affecting women in the US. The Cancer Genome Atlas Network identified p53 mutations in 96% of high-grade serous ovarian carcinomas, demonstrating its critical role. Additionally, the Transforming Growth Factor Beta (TGFβ) pathway is dysfunctional in various malignancies, including ovarian canc...
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Full title
Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer
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TN_cdi_plos_journals_1500751588
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1500751588
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0089553
