Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 di...
Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not clear. We hypothesized that differential susceptibility of Idd mouse strains to...
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Full title
Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes
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TN_cdi_plos_journals_1503271667
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1503271667
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0089561
