Exposure of Allium cepa Root Cells to Zidovudine or Nevirapine Induces Cytogenotoxic Changes
Exposure of Allium cepa Root Cells to Zidovudine or Nevirapine Induces Cytogenotoxic Changes
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Antiretroviral drugs have proved useful in the clinical management of HIV-infected persons, though there are concerns about the effects of exposure to these DNA-reactive drugs. We investigated the potential of the plant model Allium cepa root tip assay to demonstrate the cytogenotoxicity of zidovudine and nevirapine and as a replace-reduce-refine p...
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Full title
Exposure of Allium cepa Root Cells to Zidovudine or Nevirapine Induces Cytogenotoxic Changes
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TN_cdi_plos_journals_1504543181
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1504543181
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0090296
