5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenc...
5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is critically discussed. A possible reason for reduced osteogenic potential may be an age-related deterioration of the Ad-MSCs. In long term in vitro culture, epigenomic changes in DNA methylation are known to cause gene silencing, affecting stem cell gr...
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Full title
5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation
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TN_cdi_plos_journals_1504771518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1504771518
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0090846
