Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells
Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Microcystins are potent phosphatase inhibitors and cellular toxins. They require active transport by OATP1B1 and OATP1B3 transporters for uptake into human cells, and the high expression of these transporters in the liver accounts for their selective hepatic toxicity. Several human tumors have been shown to have high levels of expression of OATP1B3...
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Full title
Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells
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TN_cdi_plos_journals_1506075891
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1506075891
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0091476
