Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Drosophila Male Germline
Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Drosophila Male Germline
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United States: Public Library of Science
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English
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United States: Public Library of Science
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When a dicentric chromosome breaks in mitosis, the broken ends cannot be repaired by normal mechanisms that join two broken ends since each end is in a separate daughter cell. However, in the male germline of Drosophila melanogaster, a broken end may be healed by de novo telomere addition. We find that Chk2 (encoded by lok) and P53, major mediators...
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Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Drosophila Male Germline
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TN_cdi_plos_journals_1507833948
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1507833948
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004130
